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Understanding the effects of maternal undernutrition in early gestation on placental development in late gestation
(University of Missouri--Columbia, 2018)
acid transporter, in restricted placentae.These changes in placentae from dams fed a nutrient restricted diet suggestsome compensation to ensure adequate nutrients are available to the fetus forproper development.I also examined the effects MUN...
Friends in high places : ecology of mycorrhizal associations in alpine plant communities
(University of Missouri--Columbia, 2010)
Mutualisms are ubiquitous in nature, yet these interactions often vary in strength and persistence. This variation raises the questions of what determines whether mutualisms persist or vanish, and how does variation in the ...
Generating temperature sensitive inteins for studying gene functions
(University of Missouri--Columbia, 2008)
Reversible and easy to use, temperature-sensitive (TS) mutations, are powerful tools to study the functions of all genes, including essential and pleiotropic ones. However, the rarity of TS alleles and the difficulty of ...
Cellular behaviors regulating tangential migration of facial branchiomotor neurons in the zebrafish embryo
(University of Missouri--Columbia, 2009)
Development of the nervous system is characterized by intricate processes like neuronal migration, axon outgrowth and guidance and synaptic connections to their targets. These processes involve navigation of the migrating ...
The Agrobacterium tumefaciens min system contributes to the regulation of cell division
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In A. tumefaciens, the essential FtsZ protein is located at the growth pole before shifting to the mid-cell right before division. Recruitment of FtsZ to mid-cell is required...
Characterizing a model of early human placenta
(University of Missouri--Columbia, 2020)
been learned about the structures of the embryo formed during this time, but any experimentation to determine function is impossible. This is not only due to ethical restrictions but also due to the fact that women are unaware of when implantation...
Mating systems in Nicotiana longiflora and N. Plumbaginifolia : the effect of interspecific interactions
(University of Missouri--Columbia, 2008)
The research presented here was focused on the effects of interactions between Nicotiana longiflora and N. plumbaginifolia on their mating systems. First, I conducted a series of observations and pollination experiments ...
The secret lives of African forest elephants: using genetics, networks, and telemetry to understand sociality
(University of Missouri--Columbia, 2012)
Knowledge of social structure is important to understanding the overall evolution and behavioral ecology of a species as it ultimately influences spatial patterns and gene flow. This dissertation focuses on the social ...
Neuroscience tools in novel contexts: developing thermogenetics in Drosophila and decoding autonomic activity in mouse major pelvic ganglion
(University of Missouri--Columbia, 2022)
Animal research models provide the opportunity to decode neural activity via the ability to precisely stimulate and record neural events associated with quantifiable circuit and behavioral outputs (Bernstein et al., 2012; Boyden et al., 2005...
Novel approach to assessment of efficacy of platelet inhibition by clopidogrel and aspirin in healthy dogs
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Introduction: Antiplatelet therapy, including clopidogrel and aspirin, is used to decrease the risk of thromboembolism in dogs. However, efficacy of therapy...
Genome-wide exploration of direct GBX2 target genes and their contributions to mouse development
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The cells that comprise the vertebrate nervous system require molecular cues to determine their cellular position, identity and their ability to make appropriate connections...
Flipping the switch : regulation of proliferation and differentiation in adult muscle stem cells
(University of Missouri--Columbia, 2011)
Adult muscle stem cells or satellite cells are the committed somatic stem cells responsible for maintenance and regeneration of adult skeletal muscle tissue. Skeletal muscle is capable of multiple rounds of complete ...
Conservation and ecology of breeding landbirds in a riparian restoration context
(University of Missouri--Columbia, 2006)
While $14 to $15 billion have been invested in 37,000+ river and stream restoration projects in North America since 1990, only 10% are monitored for biological function. My work examines factors that affect landbird ...
Beyond the edge : riparian habitat use and forest management effects on stream salamanders in the southern Appalachian mountains
(University of Missouri--Columbia, 2007)
While there are many types of habitat loss and degradation (e.g., agriculture, land development), many studies have focused on the impacts of logging on wildlife populations and on ecosystem processes. Little information, ...
Regulation of ceramide synthase 1 in cellular stress response
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ceramides are intimately involved in a wide range of cellular processes. In mammals, de novo ceramide synthesis is catalyzed by the 6 ceramide synthase enzymes, which...
Approaches for unveiling the kinetic mechanisms of voltage gated ion channels in neurons
(University of Missouri--Columbia, 2019)
Ionic currents drive cellular function within all living cells to perform highly specific tasks. For excitable cells, such as muscle and neurons, voltage-gated ion channels have finely tuned kinetics that allow the ...
Establishing a foundation for large DNA transfer to artificial minichromosomes and B insert platforms in maize
(University of Missouri--Columbia, 2019)
In plants, conventional genetic engineering methods limit the number of available traits that could potentially improve the quality of agriculture. Agrobacterium-mediated transformation and biolistic bombardment are tools ...
Regulation of plant development in Arabidopsis
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The development of a complex organism, such as a plant, requires the function of multiple pathways that regulate various aspects of the developmental process. Here pathways...
Intervertebral discs : metabolic responses to load, injury, and pro-inflammatory stimulation
(University of Missouri--Columbia, 2020)
Introduction: Intervertebral disc (IVD) degeneration is a significant cause of back pain and disability. Factors such as trauma and magnitude and frequency of loading are associated with IVD degeneration. However, the ...
Genetic and hormonal regulation of meristem initiation and maintenance pathways during maize vegetative and reproductive development
(University of Missouri--Columbia, 2021)
Plant development is driven by pools of undifferentiated stem cells called meristems. Meristems have two functions, to divide producing cells that will replenish the stem-cell niche, and cells that will differentiate into ...